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Preclinical study reveals increased susceptibility to mechanical stretch in keloid fibroblasts, highlighting mechanotransduction as a key driver of disease persistence.
Keloids are a common fibrotic disease of the skin, with the pathological hallmark of excessive extracellular matrix synthesis due to abnormal fibroblast activity. Since keloids clinically arise in areas of high mechanical tension, the mechanotransductory pathway may be attributed to its pathogenesis. We aimed to establish a preclinical platform to elucidate the underlying mechanism of keloid development and its clinical persistence.
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Kim et al. (2024) studied this question.
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