In Belgium, around a quarter of M. genitalium infections are resistant to both macrolides and fluoroquinolones -termed multi-drug-resistant (MDR) infections. It is unclear what the best treatment is for these infections. We report the first two cases of MDR M. genitalium urethritis treated with combination therapy of minocycline, metronidazole, methenamine and pristinamycin. In both cases, this treatment resulted in microbiological and clinical cure.
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Chris Kenyon (2024) studied this question.
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