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Cytokines such as Tumor necrosis factor-alpha (TNF-α), Interleukin 6 (IL6), Interferon-gamma (IFN-γ), Interleukin 17-alpha (IL17-α), and Interleukin 33 (IL33), play critical roles in immune responses, and may impact cancer prognosis in future. However, few studies have simultaneously explored the prognostic impact of these cytokines for cancer. In this study, we aim to apply the unsupervised clustering analysis to approach the correlation between the expression of these cytokines and the subsequent prognosis of patients with esophageal squamous cell carcinoma.
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Chuang et al. (2024) studied this question.
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