Ex vivo cultivated oral mucosal epithelial cell transplantation (COMET) was first introduced in Japan in June 2021. This technique is used to treat limbal stem cell deficiency (LSCD). This article provides a detailed description of one of the most critical steps in COMET, which is the harvesting of oral mucosa, along with accompanying videos. The samples harvested using this method were successfully cultured into cell sheets, which were then used in surgical procedures without complications.
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Hiroshi Toshida (2024) studied this question.
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