Figure S2 from E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response Network

Suppementary metabolomics data: (A) Heat map determining top hits of metabolite ions in all cell lines at 24 hrs time-point post METi (|log2FC| > 0.5; adj.P value < 0.01). (B) Differences in metabolite ions (dots) abundance in METi-treated (24 hrs) and control cells. Statistically significant differences (|log2FC| > 0.5; P value < 0.01) are highlighted dark blue. (C) Enrichment analysis of the metabolomics data for GTL-16 and EBC-1 cells after 50 nM METi for 24 hrs, focusing on purine-related pathways.