Supplementary Figure 2 from Telomerase upregulation induces progression of mouse BrafV600E-driven thyroid cancers and triggers non-telomeric effects

Iñigo Landa; Caitlin E.M. Thornton; Bin Xu; Jacob Haase; Gnana P. Krishnamoorthy; Jingzhu Hao; Jeffrey A. Knauf; Zachary T. Herbert; Paula Martínez; Marı́a A. Blasco; Ronald Ghossein; James A. Fagin

doi:10.1158/1541-7786.27035431

September 16, 2024

Supplementary Figure 2 from Telomerase upregulation induces progression of mouse BrafV600E-driven thyroid cancers and triggers non-telomeric effects

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Key Points

Telomerase upregulation induces progression of murine BrafV600E-driven thyroid cancers, while triggering distinct non-telomeric effects in dual Braf and Tert tumors.
Analysis of murine tumor phenotypes identifies additional features separating Braf from combined Braf and Tert thyroid cancers within established experimental models.
Findings highlight how telomerase activation accelerates Braf-mediated thyroid carcinogenesis; mouse model requires further preclinical and clinical investigation.

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Implication

Murine study reveals progression of BrafV600E-driven thyroid cancers upon telomerase upregulation, highlighting non-telomeric effects in Braf and Tert tumors.

Abstract

Additional features of Braf and Braf+Tert murine tumors.

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Landa et al. (2024) studied this question.

synapsesocial.com/papers/68e5857ab6db64358752235b https://doi.org/10.1158/1541-7786.27035431

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Supplementary Figure 2 from Telomerase upregulation induces progression of mouse BrafV600E-driven thyroid cancers and triggers non-telomeric effects

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 2 from Telomerase upregulation induces progression of mouse BrafV600E-driven thyroid cancers and triggers non-telomeric effects

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

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