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September 16, 2024

Supplementary Figure S4 from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer

Catherine Lee Ziyue Karen Jiang Simon Planken Lisa K. Manzuk Roberto Ortiz Michael Hall Kavon Noorbehesht Sripad Ram Timothy Affolter Gabriel E. Troche Nathan T. Ihle Theodore Johnson Youngwook Ahn Manfred Kraus Anand Giddabasappa

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Abstract

Baseline differences in tumor progression and histopathology of G12D versus G12C KP GEM models

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Lee et al. (2024) studied this question.

synapsesocial.com/papers/68e58589b6db643587522516 https://doi.org/10.1158/1535-7163.27035953

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024
2Supplementary Figure S7 from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024
3Supplementary Figure S7 from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024
4Supplementary Figure S6 from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024
5Supplementary Figure S6 from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024

Supplementary Methods from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024
Supplementary Methods from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024
Supplementary Figure S5 from Efficacy and Imaging Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer2024