Supplementary Figure S17 from Multiomic mapping of acquired chromosome 1 copy number and structural variants to identify therapeutic vulnerabilities in multiple myeloma.

Differential methylation of MM relevent genes. Volcano plots of the CpG probes (probes=2498) across chromosome 1 between MM (n=161) and normal PC (n=3), as a result there are 378 probes (genes=360) that are significantly hypomethylated in MM on in comparison to the normal phenotype and 5 probes (genes=7) are significantly hypermethylated. The plot is further annotated to show the probe associated with A. the GEP70 genes located on chromosome 1 (n=20, p-arm=12, q-arm=8), and B. genes that have been previously implicated as driver genes of the gain/1amp(1q) phenotype in MM (n=20, p-arm=7, q-arm=13).