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This is a Experimental Study study.

October 7, 2025MoleculesOpen Access

Discovery of Primaquine–Indole Carboxamides with Cancer-Cell-Selective Antiproliferative Activity

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Compound 2 showed enhanced antiproliferative effects compared to primaquine alone.
Significant apoptosis in tested cancer cell lines was linked to the generation of reactive oxygen species.
Combination therapies with indole carboxamides could present a novel approach to treating cancer.
This research highlights the potential of using existing drugs like primaquine in new cancer treatment strategies.

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Identifies Primaquine-Indole Carboxamide conjuagates' enhanced antiproliferative effects in cancer cells, suggesting potential cancer therapies.

Peer et al. (2025) studied this question.

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Identifies Primaquine-Indole Carboxamide conjuagates' enhanced antiproliferative effects in cancer cells, suggesting potential cancer therapies.