Supplementary Figure S5 from Prediagnostic prescription antibiotics use and survival in colorectal cancer patients: A Swedish national register-based study

Supplementary Figure S5: Antibiotics use in relation to overall and cancer-specific survival in stage I-III colorectal cancer patients by antibiotics classes, typical indications and specific antibiotics drugs. The hazards ratios (HR) are derived from the Cox proportional hazards models, stratified by tumour sites (proximal colon/distal colon/rectum/unspecified colorectum categories) and tumour stage (stage I-III), age at diagnosis (</≥ 50 years), prediagnostic Charlson comorbidity index (no/any CCI), family history of colorectal cancer (0/1/≥2 first degree relatives ), and adjusted for: age and calendar year of diagnosis and prediagnostic Charlson comorbidity index as continuous variables, and sex, place of birth, county of residence, marital status, level of education and income status as categorical variables, defined as presented in Table 1. Antibiotics use during one year before colorectal cancer diagnosis was excluded to account for potential use due to undiagnosed but clinically manifest colorectal cancer. Any use of specific antibiotics class was compared with no use of the specific antibiotics class (reference category). Antibiotics that primarily or only affect aerobic bacteria were categorized as aerobic antibiotics. Antibiotics with effect on both anaerobic and aerobic bacteria, and metrodinazoles and/or tinidazoles (which only affect anaerobic bacteria) were categorized as anti-anaerobic antibiotics. Phenoxymethylpenicillin is presented as a specific antibiotic drug but was also the sole typical drug for the indication uncomplicated respiratory infections and some skin and soft tissue infections. Clindamycin is presented as a specific antibiotic drug but was also the sole typical drug for the indication complicated skin and soft tissue and deep-seated infections. Amoxicillin includes amoxicillin with beta-lactamase inhibitor. UTI = urinary tract infection, CI = confidence interval. Detailed antibiotics classification and typical indications are presented in Supplementary Table S1.