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September 16, 2024

Supplementary Figure S5 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

Kathryn Gunn Matti Myllykoski John Z. Cao Manna Ahmed Bofu Huang Betty Rouaisnel Bill H. Diplas Michael M. Levitt Ryan Looper John G. Doench Keith L. Ligon Harley I. Kornblum Samuel K. McBrayer Hai Yan Cihangir Duy Lucy A. Godley Peppi Koivunen Julie-Aurore Losman

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Abstract

Characterization of KDM5A mutants.

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Gunn et al. (2024) studied this question.

synapsesocial.com/papers/68e586c1b6db6435875233c1 https://doi.org/10.1158/2159-8290.27025175

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S5 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
2Supplementary Figure S7 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
3Supplementary Figure S7 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
4Supplementary Figure S2 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
5Supplementary Figure S2 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024

Supplementary Figure S6 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
Supplementary Figure S6 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
Supplementary Figure S8 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024