A prostate tumor cell line (PC3M-A2/beta 2M) was inoculated subcutaneously in the right flank of CD34-humanized NSG mice. Mice were treated intravenously at indicated time points with either vehicle or with an ABBV-184 precursor molecule, and tumor size was monitored. Tumors experienced transient regression and growth inhibition prior to harvest for analysis of tumor-infiltrating immune cells.
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Chervin et al. (2024) studied this question.
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