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September 16, 2024

Supplementary Video S1 from RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

Vivek Subbiah Vaibhav Sahai Dejan Maglic Kamil Bruderek B. Barry Touré Songping Zhao Roberto Valverde Patrick J. O’Hearn Demetri T. Moustakas Heike Schönherr Nastaran Gerami-Moayed Alexander M. Taylor Brandi M. Hudson Damian J. Houde Debjani Pal Lindsey Foster Hakan Günaydin Pelin Ayaz Dina A. Sharon Lipika Goyal Alison M. Schram Suneel Kamath Cori Ann Sherwin Oleg Schmidt‐Kittler Kai Yu Jen Fabien Ricard Beni B. Wolf David E. Shaw Donald A. Bergstrom James Watters Jessica B. Casaletto

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Abstract

In this schematic movie, apo FGFR1 (left panel) demonstrates rapid P-loop dynamics, while apo FGFR2 (right panel) displays less P-loop motion.

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Subbiah et al. (2024) studied this question.

synapsesocial.com/papers/68e586c1b6db643587523af5 https://doi.org/10.1158/2159-8290.27025745

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1Supplementary Video S1 from RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations2024
2Supplementary Video S1 Legend from RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations2024
3Supplementary Video S1 Legend from RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations2024
4Supplementary Figure S1 from RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations2024
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Supplementary Figure S2 from RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations2024
Supplementary Figure S2 from RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations2024
Supplementary Appendix S1 from RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations2024