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Given the significant limitations of available literature, central nervous system (CNS) prophylaxis in large B‐cell lymphomas remains debatable. Wilson and colleagues provide cautious recommendations, on a case‐by‐case basis, useful to guide discussion with individual patient. In daily practice, CNS relapse risk, prophylaxis safety and prognosis of CNS recurrence must be considered. Commentary on: Wilson et al. Central nervous system prophylaxis in large B‐cell lymphoma: A British Society for Haematology Good Practice Paper. Br J Haematol 2024; 205: 2198‐2205 .
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Calimeri et al. (2024) studied this question.
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