Research Progress of Cryptosporidium Adhesion and Gliding Motility Related Proteins

This review focuses on the complex molecular mechanisms involved in the adhesion and gliding motility of Cryptosporidium, emphasizing the importance of these processes in Cryptosporidium infection and summarizing the virulence factors involved. Subsequently, The manuscript meticulously examines the functional profiles and the chronicled research trajectories of adhesion-associated virulence factors, namely CSL, gp40/15, and gp900. In parallel, it explores the repertoire of factors implicated in gliding motility, including TRAP-C1, Cptsp4, and CpROM. Each factor is contextualized within the broader framework of the parasite's engagement with host defenses and its evasion strategies. Moreover, the review prognosticates the prospective research avenues that these factors are poised to influence, offering a measured appraisal of their viability as targets for vaccine and therapeutic development. The discourse encapsulates the current state of knowledge while venturing into the uncharted territories of potential, thereby establishing a robust foundation for future investigative endeavors aimed at demystifying the biological intricacies and pathogenic mechanisms of Cryptosporidium.