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September 13, 2024Science ImmunologyOpen Access

CD4 ⁺ T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy

Steven P. Wolf Matthias Leisegang Madeline Steiner V.C.J. Wallace Kazuma Kiyotani Yifei Hu Leonie Rosenberger Jun Huang Karin Schreiber Yusuke Nakamura Andrea Schietinger Hans Schreiber

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Abstract

Cancers eventually kill hosts even when infiltrated by cancer-specific T cells. We examined whether cancer-specific T cell receptors of CD4

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Wolf et al. (2024) studied this question.

synapsesocial.com/papers/68e58930b6db6435875255fa https://doi.org/10.1126/sciimmunol.adp6529

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1CD4+ T cells in cancer: dual roles, exhaustion, and therapeutic breakthroughsOriginal Research · 2026 · 3 citations
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4Abstract 3606: Tumor-specific CD8+ Tc9 cells activate host CD4+ T cells to control antigen-lost tumors2024
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