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September 13, 2024XenobioticaOpen Access

A modelling approach to compare ADC deconjugation and systemic elimination rates of individual drug-load species using native ADC LC-MS data from human plasma

Shawna Hengel Ariel R. Topletz‐Erickson Hossam Kadry Stephen C. Alley

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Abstract

Native liquid chromatography mass spectrometry (LC-MS) is a commonly used approach for intact analysis of inter-chain cysteine conjugated antibody-drug conjugates (ADCs). Coupling native LC-MS with affinity capture provides a platform for intact ADC analysis from

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Hengel et al. (2024) studied this question.

synapsesocial.com/papers/68e58936b6db643587525869 https://doi.org/10.1080/00498254.2024.2340741

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Rapid and selective characterization of antibody-drug conjugates in complex sample matrices by native affinity liquid chromatography-mass spectrometry.Original Research · 2026 · 4 citations
2Intact quantitation of cysteine‐conjugated antibody‐drug conjugates using native mass spectrometry2024 · 12 citations
3Digestion-Free Middle-Down Mass Spectrometry Method for Absolute Quantification of Conjugated Payload from Antibody-Drug Conjugates2024 · 14 citations
4Digestion-Free Middle-down Mass Spectrometry Method for Absolute Quantification of Conjugated Payload from ADCs2024
5LC/MS/MS Bioanalysis of Protein–Drug Conjugates—The Importance of Incorporating Succinimide Hydrolysis ProductsOriginal Research · 2018 · 20 citations

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Digestion-Free Absolute Quantification of Conjugated Payload from ADCs Using Middle-Down Fragmentation Mass Spectrometry2024

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