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September 13, 2024Analytical Chemistry

Efficient Capture and Traceless Release of Functional CD8⁺ T Cells with a Microfluidic Chip for Enhanced In Vitro and In Vivo CD4-CAR Transduction

Aynur Abdulla Tuersunayi Abudureheman Kai‐Ming Chen Behafarid Ghalandari Haoni Yan Hang Zhou Hengxing Su Yun‐Qian Zhang Cai‐Wen Duan Xianting Ding

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Abstract

The chimeric antigen receptor (CAR) T cells targeting CD4 expressed cells in acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML) could reduce the risk of off target effects in normal tissues. However, the efficacy of adoptive cell therapy is predominantly attributed to CD8

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Cite This Study

Abdulla et al. (2024) studied this question.

synapsesocial.com/papers/68e58a50b6db643587525e11 https://doi.org/10.1021/acs.analchem.4c03135

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Efficient Combinatorial Adaptor-Mediated Targeting of Acute Myeloid Leukemia with CAR T-Cells2024
2CAR T cell cytotoxic responses are rapidly generated and sensitive to the unligated TCR2025
3Efficient combinatorial adaptor-mediated targeting of acute myeloid leukemia with CAR T-cells2024 · 20 citations
4Microfluidic Hydroporation Platform for Effective Allogeneic CAR‐T Cell Production and Subsequent Functional Cytotoxicity AnalysisOriginal Research · 2026 · 2 citations
5Efficient and Traceless Aptamer‐Based Serial Selection of Naïve and Early Memory CD8 T Cells for CAR T Cell Therapy2025 · 3 citations

More related papers

Engineered CD4 T cells for in vivo delivery of therapeutic proteins2024
Improving cell reinfusion to enhance the efficacy of chimeric antigen receptor T-cell therapy and alleviate complications2024
Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells2019

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