Figure S2 from Tumor-Immune Signatures of Treatment Resistance to Brentuximab Vedotin with Ipilimumab and/or Nivolumab in Hodgkin Lymphoma

Supplemental Figure 2. Cellular marker dynamics in Hodgkin lymphoma during checkpoint blockade treatment. A. Heatmap showing markers and cell types identified through CyTOF (cytometry using time of flight) that significantly change over time. The color indicates the standardized Log2FC in protein expression (Z-Score), and the size of the circles indicate the percent of cells expressing the marker. A dendrogram of the markers sorted hierarchically is shown on the right side. B. Line plots highlight the temporal changes for each of the markers shown in A. The color separates the values per treatment. C. Heatmap showing markers and cell types significantly associated with R (Responder) and NR (Not responder). D. Regression lines for examples of markers and cell types shown in C, separating response (R) and non-response (NR).