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September 13, 2024

An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation

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Authors

MRMónica Román-TruferoIKIstvan T. KleijnKBKevin Blighe

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Cite This Study

Román-Trufero et al. (2024) studied this question.

synapsesocial.com/papers/68e58a50b6db643587525fddhttps://doi.org/10.1101/2024.09.10.611650
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GCN2 in Proteostasis: Structural Logic, Signalling Networks, and Disease2026
  2. 2Abstract 450: GCN2 protects cancer cells from hypertranslation and metabolic crisis2024
  3. 3GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling2025
  4. 4An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity2026 · 3 citations
  5. 5In Vivo Tumor Growth Control by General Control Nonderepressible 2 Targeting Agents Results from Kinase Activation2025 · 1 citations