Supplementary Figure S9 from Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer

Christopher J. Sweeney; Russell Petry; Chang Xu; Merrida Childress; Jie He; David Fabrizio; Ole Gjoerup; Samantha Morley; Timothy Catlett; Zoe J. Assaf; Kobe Yuen; Matthew Wongchenko; Kalpit Shah; Pratyush Gupta; Priti Hegde; Lincoln W. Pasquina; Sanjeev Mariathasan; Ryon P. Graf; Thomas Powles

doi:10.1158/1078-0432.27013667

Key Points

Tracking on-treatment circulating tumor DNA tumor fraction adds prognostic value beyond standard prostate-specific antigen response in advanced disease.
A thirty percent prostate-specific antigen reduction alongside circulating tumor DNA clearance stratifies patient outcomes during active treatment.
Evaluation of circulating tumor DNA tumor fraction complements clinical treatment monitoring, indicating improved assessment in prostate cancer.

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Implication

Observational analysis demonstrates prognostic value of circulating tumor DNA and PSA reduction in metastatic castration-resistant prostate cancer, highlighting enhanced treatment monitoring.

Abstract

Prognostic value of on-treatment ctDNA TF detection and 30% PSA reduction

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Sweeney et al. (2024) studied this question.

synapsesocial.com/papers/68e58a5ab6db64358752637c https://doi.org/10.1158/1078-0432.27013667

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Supplementary Figure S9 from Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S9 from Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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