Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps

Álvaro Teijeira; Saray Garasa; María C. Ochoa; Sandra Sánchez‐Gregorio; Gabriel Gomis; Carlos Luri‐Rey; Rafael Martínez‐Monge; Beatrice Pinci; Karmele Valencia; Belén Palencia; Benigno Barbés; Elixabet Bolaños; Arantza Azpilikueta; Marina García-Cardosa; Javier Burguete; Iñaki Eguren‐Santamaría; Eneko Garate-Soraluze; Pedro Berraondo; José Luis Pérez‐Gracia; Carlos E. de Andrea; María E. Rodríguez-Ruiz; Ignacio Melero

doi:10.1158/1078-0432.27013546.v1

Key Points

Low-dose ionizing radiation triggers the secretion of autocrine interleukin-8, which subsequently promotes the formation of neutrophil extracellular traps.
Exposure to low-dose gamma irradiation elicits rapid cellular cytokine release, serving as a primary autocrine stimulus across experimental cellular assays.
These observations highlight autocrine interleukin-8 signaling during radiation exposure; in vitro cell model, so further preclinical work is needed.

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Implication

Laboratory assay demonstrates autocrine interleukin-8 secretion in irradiated cells, highlighting an endogenous signaling pathway driving neutrophil extracellular trap extrusion.

Abstract

Supplementary Figure S1. Autocrine IL-8 is secreted upon low-dose g-irradiation.

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Teijeira et al. (2024) studied this question.

synapsesocial.com/papers/68e58a5ab6db6435875264cd https://doi.org/10.1158/1078-0432.27013546.v1

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Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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