Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

Susan Pereira Ribeiro; Zachary Strongin; Hugo Soudeyns; Felipe ten-Caten; Khader Ghneim; Gabriela Pacheco Sánchez; Giuliana Xavier de Medeiros; Perla M. Del Río Estrada; Adam‐Nicolas Pelletier; Timothy N. Hoang; Kevin Nguyen; Justin Harper; Sherrie Jean; Chelsea Wallace; Robert Balderas; Jeffrey D. Lifson; G. Raghunathan; Eric Rimmer; Cinthia Pastuskova; Guoxin Wu; Luca Micci; Ruy M. Ribeiro; Chi Ngai Chan; Jacob D. Estes; Guido Silvestri; Daniel M. Gorman; Bonnie J. Howell; Daria J. Hazuda; Mirko Paiardini; Rafick‐Pierre Sékaly

doi:10.1038/s41590-024-01952-4

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

Human immunodeficiency virus (HIV) persistence during antiretroviral therapy (ART) is associated with heightened plasma interleukin-10 (IL-10) levels and PD-1 expression. We hypothesized that IL-10 and PD-1 blockade would lead to control of viral rebound following analytical treatment interruption (ATI). Twenty-eight ART-treated, simian immunodeficiency virus (SIV)mac

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Ribeiro et al. (2024) studied this question.

synapsesocial.com/papers/68e58a69b6db643587526a70 https://doi.org/10.1038/s41590-024-01952-4

View Full Paper

Ask AI

Bookmark

Share

Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

Ask about this paper

Abstract

Discussion

Cite This Study

Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading