TREX1 expression is induced in posttreated human SCLC tumors. A, IF staining of CK + EpCAM (green), TREX1 (red) protein in patient 25 and patient 6 SCLC tumors are shown, pre- and post-chemotherapy treatment. B, TREX1 IF intensity in 10 patients is compared between pre- and post-chemotherapy treatment. C, TREX1 IHC intensity in a paired PDX tumor is compared between pre- and post-chemotherapy treatment. Scale bar, 100 μm. Data represent mean ± SEM. ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 by paired Student t test (B).
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Murayama et al. (2024) studied this question.
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