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September 11, 2024BJC ReportsOpen Access

Small extracellular vesicles as biomarkers of response in recurrent/metastatic HNSCC patients treated with immunotherapy

Dan P. Zandberg Chang-Sook Hong Andrew W. Swartz Ronan W. Hsieh Jennifer Anderson Robert L. Ferris Brenda Diergaarde Theresa L. Whiteside

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Abstract

Biomarkers that effectively predict response to anti-PD-1 mAb therapy in cancer patients are an unmet need. We evaluated the utility of small extracellular vesicles (sEV) as biomarkers of response to immunotherapy in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) patients.

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Cite This Study

Zandberg et al. (2024) studied this question.

synapsesocial.com/papers/68e58cbfb6db643587528532 https://doi.org/10.1038/s44276-024-00096-0

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Extracellular vesicle‐based biomarker in head and neck cancer: prospects and challenges2024 · 2 citations
2Extracellular vesicles in head and neck cancer: mediators of oncogenesis, immune evasion, and therapy resistance2025 · 5 citations
3Identification of von Willebrand Factor-Enriched Small Extracellular Vesicles as a Blood-Based Biomarker for the Detection of Head and Neck Squamous Cell CarcinomaOriginal Research · 2026
4Flow-cytometric profiling of large extracellular vesicles as immunophenotypic biomarkers in head and neck squamous cell carcinomaOriginal Research · 2026
5Predictive circulating small extracellular vesicle miRNAs for immunochemotherapy response in ES-SCLC.Cohort Study · 2026

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Analysis of circulating small extracellular vesicle-associated miRNA in head and neck squamous cell carcinoma (HNSCC): Biomarker discovery in pre-operative neoadjuvant nivolumab.2026
Extracellular vesicles as diagnostic and prognostic biomarkers in non-small cell lung Cancer2026
Plasma extracellular vesicles reflect response and prognosis in patients with breast cancer undergoing neoadjuvant treatment2026

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