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September 11, 2024Open Access

Axin1 and Axin2 regulate the WNT-signaling landscape to promote distinct mesoderm programs

Rocío Hernández-Martínez Sonja Nowotschin Luke Harland Ying-Yi Kuo Bart Theeuwes Berthold Göttgens Elizabeth Lacy Anna‐Katerina Hadjantonakis Kathryn V. Anderson

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Abstract

How distinct mesodermal lineages - extraembryonic, lateral, intermediate, paraxial and axial - are specified from pluripotent epiblast during gastrulation is a longstanding open question. By investigating AXIN, a negative regulator of the WNT/β-catenin pathway, we have uncovered new roles for WNT signaling in the determination of mesodermal fates. We undertook complementary approaches to dissect the role of WNT signaling that augmented a detailed analysis of

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Cite This Study

Hernández-Martínez et al. (2024) studied this question.

synapsesocial.com/papers/68e58cc8b6db6435875285fa https://doi.org/10.1101/2024.09.11.612342

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