[¹⁸⁶Re]Re- and [99mTc]Tc-Tricarbonyl Metal Complexes with 1,4,7-Triazacyclononane-Based Chelators Bearing Amide, Alcohol, or Ketone Pendent Groups

Rebecca Hoerres; Ritin Kamboj; Nora Pryor; Steven P. Kelley; Heather M. Hennkens

doi:10.1021/acsomega.4c05699

September 11, 2024ACS OmegaOpen Access

[¹⁸⁶Re]Re- and [99mTc]Tc-Tricarbonyl Metal Complexes with 1,4,7-Triazacyclononane-Based Chelators Bearing Amide, Alcohol, or Ketone Pendent Groups

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Key Points

Chelators based on 1,4,7-triazacyclononane bearing amide, alcohol, or ketone pendent groups show high promise as bifunctional chelators for rhenium-186 and technetium-99m tricarbonyl cores.
Frameworks including NOTA and NODAGA demonstrate efficacy as bifunctional chelators when binding tricarbonyl metal complexes of rhenium-186 alongside technetium-99m radioisotopes.
Analysis of 1,4,7-triazacyclononane derivatives confirms versatile chelation, supporting the ongoing design of targeted rhenium-186 and technetium-99m radiopharmaceutical complexes.

Implication

Experimental evaluation demonstrates synthesis of rhenium and technetium tricarbonyl complexes with triazacyclononane chelators, highlighting their promise as bifunctional chelating agents.

Abstract

1,4,7-Triazacyclononane (TACN)-based chelators, such as NOTA and NODAGA, have shown great promise as bifunctional chelators for [M(CO)

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Hoerres et al. (2024) studied this question.

synapsesocial.com/papers/68e58dd5b6db643587528fd1 https://doi.org/10.1021/acsomega.4c05699

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[¹⁸⁶Re]Re- and [99mTc]Tc-Tricarbonyl Metal Complexes with 1,4,7-Triazacyclononane-Based Chelators Bearing Amide, Alcohol, or Ketone Pendent Groups

Key Points

Implication

Abstract

Discussion

Cite This Study

[¹⁸⁶Re]Re- and [99mTc]Tc-Tricarbonyl Metal Complexes with 1,4,7-Triazacyclononane-Based Chelators Bearing Amide, Alcohol, or Ketone Pendent Groups

Key Points

Implication

Abstract

Discussion

Cite This Study

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