September 5, 2024Journal of Medicinal Chemistry

Developing a Palladium(II) Agent to Overcome Multidrug Resistance and Metastasis of Liver Tumor by Targeted Multiacting on Tumor Cell, Inactivating Cancer-Associated Fibroblast and Activating Immune Response

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Authors

MJMing JiangGuangxi Normal University WLWenjuan LiNorthwestern Polytechnical University JLJinzhe LiangMinistry of Education of the People's Republic of China

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Implication

Preclinical study reveals reduced growth and metastasis in multidrug-resistant liver tumors using an albumin-bound palladium agent, suggesting an effective strategy to counter drug resistance.

Key Points

A tailored palladium compound complexed with human serum albumin suppresses multidrug resistance and inhibits metastatic progression in liver cancer cells.
Optimization of thiosemicarbazone derivatives yielded compound 5b, which shows marked cytotoxicity against drug-resistant HepG2/ADM cells and lowers side effects.
Targeting the tumor microenvironment with albumin carriers enhances delivery; however, findings remain limited to preclinical models requiring further validation.

Cite This Study

Jiang et al. (2024) studied this question.

synapsesocial.com/papers/68e5932eb6db64358752ed5b https://doi.org/10.1021/acs.jmedchem.4c01175

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Implication

Preclinical study reveals reduced growth and metastasis in multidrug-resistant liver tumors using an albumin-bound palladium agent, suggesting an effective strategy to counter drug resistance.

Developing a Palladium(II) Agent to Overcome Multidrug Resistance and Metastasis of Liver Tumor by Targeted Multiacting on Tumor Cell, Inactivating Cancer-Associated Fibroblast and Activating Immune Response

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Key Points

Cite This Study

Developing a Palladium(II) Agent to Overcome Multidrug Resistance and Metastasis of Liver Tumor by Targeted Multiacting on Tumor Cell, Inactivating Cancer-Associated Fibroblast and Activating Immune Response

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Key Points

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