Key result
Macrophage-expressed factor VII promotes adverse cardiac remodeling in ischemic heart disease.
Excess fibrotic remodeling causes cardiac dysfunction in ischemic heart disease, driven by MAP (mitogen-activated protein) kinase-dependent TGF-ß1 (transforming growth factor-ß1) activation by coagulation signaling of myeloid cells. How coagulation-inflammatory circuits can be specifically targeted to achieve beneficial macrophage reprogramming after myocardial infarction (MI) is not completely understood.
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Garlapati et al. (2024) studied Ischemic heart disease / Myocardial infarction. Macrophage-Expressed Coagulation Factor 7 was evaluated. Macrophage-expressed coagulation factor 7 promotes adverse cardiac remodeling in ischemic heart disease.
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