Clinical efficacy of non-eugenol containing periodontal dressing with and without platelet-rich fibrin on wound healing after surgical gingival depigmentation: a randomized clinical trial

Abstract Aim: The study aimed to evaluate the effect of platelet-rich fibrin on wound healing after surgical depigmentation Methodology: Twenty-four patients with gingival pigmentation were recruited and randomly assigned to the control group; non-eugenol periodontal dressing only, or to the test group; L-PRF with periodontal dressing. Gingival depigmentation was done using a combination of scalpel and bur techniques and both groups were covered using periodontal dressing. The healing index, epithelization test and pigmentation recurrence were tested and compared. Results: The healing index in the test group was 91.7% of the patients scored 4 (Very good) on the 5th day, while in the control group, 83.3% scored 2 (poor) on the 5th day and 16.7% were observed to have a score 3 (Good). The epithelization test was the most significant with 100% receiving a negative result in the test group after 5 days with 66.7% completely healed and 33.3% partially healed when compared to 100% of the control group having a positive score (no epithelization). The pigmentation recurrence after 6 months was observed in 66.7% in the test group while only 33.3% in the control group. Conclusion: Using PRF after gingival depigmentation results in better wound healing when compared to using periodontal packs alone.