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A metal‐free α‐(hetero)arylation of aryloxy‐activated amides for access to diaryl‐acetamides was developed. This base‐mediated arylation reaction features mild reaction conditions and broad functional groups tolerance. The scope of (hetero)arylating reagents includes indoles, pyrroles, furan, N, N‐dimethylanilines, and electron‐rich benzenes. The applicability of this protocol was demonstrated by the gram‐scale experiment and the derivatization of the target products.
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Zeng et al. (2024) studied this question.
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