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September 3, 2024Nanomedicine

LC-MS/MS method for simultaneous Doxorubicin and Baicalein estimation: formulation and pharmacokinetic applications

Pooja Yadav Sanjay Singh Divya Chauhan Pavan Kumar Yadav Amrendra Tiwari Naresh Kothuri Sonia Verma J.V.U.S. Chakradhar Mitali Sethi Jiaur R. Gayen Manish K. Chourasia

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Abstract

Aim & objective: Combinatorial delivery of Doxorubicin (DOX) and Baicalein (BAC) has a potential to improve breast cancer treatment by mitigating the cardiotoxicity induced by DOX. The nanoformulation has been optimized and subjected to pharmacokinetic studies using LC-MS/MS.

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Yadav et al. (2024) studied this question.

synapsesocial.com/papers/68e597d2b6db6435875324d3 https://doi.org/10.1080/17435889.2024.2390348

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1LC–MS/MS method development for quantification of doxorubicin and its metabolite 13‐hydroxy doxorubicin in mice biological matrices: Application to a pharmaco‐delivery studypreclinical · 2016 · 37 citations
2Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells2024 · 26 citations
3Development and validation of an LC-MS/MS method for the quantification of free and total doxorubicin in human plasma and its clinical application for a novel doxorubicin hydrochloride liposome injection in Chinese patients with breast cancerother · 2023 · 5 citations
4Subcellular Quantification of Doxorubicin and Its Metabolite in Cultured Human Leukemia Cells Using Liquid Chromatography-Tandem Mass Spectrometrypreclinical · 2012 · 9 citations
5Rutin-enabled Improved Systemic Exposure of Doxorubicin via Nanostructured Lipid Carriers: A proof of concept through novel LC-MS/MS analysisOriginal Research · 2026

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Determination of doxorubicin in plasma and tissues of mice by UPLC-MS/MS and its application to pharmacokinetic study2024

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