Figure S6 from Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor

Supplemental Figure 6. Cell populations identified by transcriptional profiling from tumor biopsies. (A) UMAP of all cells in the dataset, colored by cluster. (B-C) Relative expression of representative genes of the six major compartments across the full dataset. (D) Relative expression of IL1B, IL1R1, PDCD1, PDCDLG1, and PDCDLG2 across the full dataset. (E) The percent of each myeloid cluster that is found in each of the samples, separated into baseline and treated subgroups (Wilcoxon rank-sum test).