Figure 5 from Anti-HDGF Antibody Targets EGFR Tyrosine Kinase Inhibitor–Tolerant Cells in NSCLC Patient-Derived Xenografts

HDGF expression in naïve and osimertinib-treated PDX tumors. Formalin-fixed, paraffin-embedded sections of TM00219 PDX tumors were stained with mouse anti–HDGF antibody T221. Representative fields (10×) of staining in naïve, osimertinib-treated, or osimertinib plus anti-HDGF antibody H3–treated arms (A). Representative slides from naïve (B) and osimertinib-treated (C) tumor viewed under different power: from left to right are low power (1.5×) wide field views, medium power (10×), and high power (40×) view. Images were extracted from ImageScope view.