Elagolix to treat menstrual related symptom exacerbations in early onset Parkinson disease: A Case Report

Parkinson's Disease (PD), a progressive neurodegenerative condition, is characterized by motor difficulties, cognitive impairment, mood disturbances, and autonomic dysfunction.In pre-menopausal women, menstruation is associated with exacerbation of PD symptoms yet there are limited data to support optimal management of these patients.We present a case of a 48-year-old woman with early onset PD and worsening symptoms prior to the onset of menses.Her complex medical history contraindicated hormonal menstrual suppression.The patient was successfully treated with Elagolix, a GnRH antagonist, mitigating her cyclic PD exacerbations and achieving menstrual suppression in the setting of estrogen and progesterone therapy contraindication.Elagolix appears to have a role for menstrual suppression in patients with menstrual-related fluctuations of PD who have contraindications to or fail hormonal therapy.