Preclinical analysis reveals sex-specific differences in epigenetic alterations and renal injury markers in aging kidneys, highlighting the need to evaluate both sexes.
Although there is evidence of sex-specific differences in kidney diseases, most preclinical studies have used male rodent models. The clinical data on renal injury have typically not been stratified by sex. Our findings provide convincing evidence of sex-specific differences in age-regulated epigenetic alterations and renal injury markers. This study highlights the importance of including both sexes for better realization of underlying sex differences in signaling mechanisms of aging-related renal pathophysiology.
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Adams-Sherrod et al. (2024) studied this question.
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