Skin barrier health plays a pivotal role in both preventive and corrective skin care across all skin types. This study aimed to assess the efficacy of witch hazel (Hamamelis virginiana) extracts in treating chronic inflammation and improving skin barrier function while combating UV-induced oxidation. Through a novel ex vivo chronic inflammation model, we demonstrated the potent anti-inflammatory effects of witch hazel formula, as evidenced by the significant reduction in key pro-inflammatory cytokines, including IL-6. Additionally, the treatment showed notable improvements in barrier function markers, such as loricrin and transglutaminase-1, compared to the inflamed condition. Furthermore, utilizing an ex vivo model with UV-induced ROS elevation, the witch hazel formula displayed a remarkable reduction in ROS levels, specifically 4-Hydroxynonenal and Carbonylated protein. Our clinical studies revealed a significant enhancement in skin hydration at 15 minutes, 4 hours, and 8 hours post-application of witch hazel toner, compared to baseline and untreated sites. Moreover, barrier function evaluation using TEWL demonstrated a substantial decrease one hour after witch hazel toner application, further affirming the formula's efficacy. In conclusion, the novel formula containing witch hazel extract exhibits potent anti-inflammatory and antioxidant properties, coupled with improved skin barrier function. This well-tolerated and natural ingredient presents a promising and effective treatment option for enhancing overall skin health.
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Liu et al. (2024) studied this question.
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