A Clinicohaematological Study in Pancytopenia

Objectives: 1. Tostudythecausesandclinicalpresentationsofpancytopenia. 2. ToevaluateHaematologicalparametersinpancytopeniaalongwithBoneMarrow Examination. Methods: AretrospectivestudywasconductedatdepartmentofPathologyfromJuly2017to Feb 2020. 20 cases of pancytopenia were evaluated clinically, along with haematological parameters. Results:Among20casesstudied,Maximumnumberofcases wasintheagegroupof21 -30 years (40%) with male predominance (1.2%). Most patients present with generalized weakness.Thecommonestbonemarrowfindingwasmegaloblasticerythroidhyperplasia. The commonest cause for pancytopenia was megaloblastic anaemia (60%) followed by aplastic anaemia (25%). Other causes of pancytopenia were hypersplenism, subleukemic leukemia, multiple myloma. Conclusion: Afterstudyingthese cases in present studywe have come onthe conclusion that the commonest cause of pancytopenia is megaloblastic anaemia. The detailed primary haematologicalinvestigationsofpatientswithpancytopeniahelptodeterminethecauseof the same, which is important for planning further investigation and crucial for treatment purpose.