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August 30, 2024International Journal of Biological MacromoleculesOpen Access

Grb2 Y160F mutant mimics the wild-type monomeric state dynamics and the monomer-dimer equilibrium

Giovana C. Moreira Raphael Vinicius Rodrigues Dias Ingrid B. S. Martins Ricardo A. Fernandes Jessica Andrade Tedesco Ícaro Putinhon Caruso Alexandre Suman de Araújo Rosângela Itri Fernando A. Melo

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Abstract

The Growth factor receptor-bound protein 2 (Grb2) participates in early signaling complexes and regulates tyrosine kinase-mediated signal transduction through a monomer-dimer equilibrium. Grb2 dimeric state inhibits signal transduction whereas the monomer promotes signaling downstream. Since Grb2 dimer K

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Moreira et al. (2024) studied this question.

synapsesocial.com/papers/68e5a3f8b6db64358753e2a5 https://doi.org/10.1016/j.ijbiomac.2024.134945

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