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August 29, 2024Journal of Crohn s and Colitis

Deficiency in epithelium RAD50 aggravates UC via IL-6-mediated JAK1/2-STAT3 signaling and promotes development of colitis-associated cancer in mice

Jie Zhang Mengli Yu Tiantian Zhang Xin Song Songmin Ying Zhe Shen Chaohui Yu

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Abstract

Ulcerative colitis (UC) is one of the most important risk factors for developing colitis-associated cancer (CAC). Persistent DNA damage increases CAC risk and has been observed in patients with UC. We aimed to identify the regulatory role of RAD50, a DNA double-strand breaks (DSBs) sensor, in UC progression to CAC.

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Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e5a5efb6db64358753ff6a https://doi.org/10.1093/ecco-jcc/jjae134

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