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Observational analysis reveals links between lifestyle risk factors and clonal hematopoiesis in human cohorts, highlighting preclinical markers for rare hematologic malignancies.
Risk factors including smoking, alcohol intake, physical activity (PA), and sleep patterns have been associated with cancer risk. Clonal hematopoiesis (CH), including mosaic chromosomal alterations and clonal hematopoiesis of indeterminate potential, is linked to increased hematopoietic cancer risk and could be used as common preclinical intermediates for the better understanding of associations of risk factors with rare hematologic malignancies.
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Young et al. (2024) studied this question.
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