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August 29, 2024mBioOpen Access

Critical roles of Dpb3-Dpb4 sub-complex of DNA polymerase epsilon in DNA replication, genome stability, and pathogenesis of Candida albicans

Bhabasha Gyanadeep Utkalaja Shraddheya Kumar Patel Satya Ranjan Sahu Abinash Dutta Narottam Acharya

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Abstract

DNA polymerase ε (Polε) is an essential replicative polymerase consisting of Pol2, Dpb2, Dpb3, and Dpb4 subunits and has not been explored in the pathogenic yeast

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Cite This Study

Utkalaja et al. (2024) studied this question.

synapsesocial.com/papers/68e5a5fbb6db643587540a05 https://doi.org/10.1128/mbio.01227-24

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Analysis of the Essential Functions of the C-terminal Protein/Protein Interaction Domain of Saccharomyces cerevisiae pol ε and Its Unexpected Ability to Support Growth in the Absence of the DNA Polymerase DomainOriginal Research · 1999 · 197 citations
2Proficient Replication of the Yeast Genome by a Viral DNA PolymeraseOriginal Research · 2016 · 8 citations
3Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis.2025
4DNA polymerase ζ in DNA replication and repairOriginal Research · 2019 · 106 citations
5Loss of Pol32, a subunit of DNA polymerases δ and ζ, leads to different patterns of genome stability than direct impairment of these individual polymerasesOriginal Research · 2026

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Genetic dissection of DNA damage tolerance in Bacillus subtilis : RecA and recombination functions regulate translesion synthesis2026
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