Mechanistic review demonstrates high uric acid induces ferroptosis in cardiac tissue, highlighting ros-gpx4 signaling as a therapeutic target for cardiomyopathy.
High uric acid (HUA), as a pro-oxidant, plays a significant role in the pathophysiology of cardiovascular disease. Studies have indicated that elevated uric acid levels can adversely affect cardiovascular health. Nevertheless, the impact of hyperuricemia on cardiomyopathy remains uncertain. Further research is needed to elucidate the relationship between HUA and cardiomyopathy, shedding light on its potential implications for heart health.
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Xu et al. (2024) studied this question.
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