Validation study demonstrates direct detection of seven antimicrobial resistance markers in 18 pathogens via cell-free DNA, highlighting a non-invasive diagnostic tool.
Sequencing of plasma microbial cell-free DNA (mcfDNA) has gained increased acceptance as a valuable adjunct to standard-of-care testing for diagnosis of infections throughout the body. Here, we report the analytical and clinical validation of a novel application of mcfDNA sequencing, the non-invasive detection of seven common antimicrobial resistance (AMR) genetic markers in 18 important pathogens. The AMR markers include SCC
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Christians et al. (2024) studied this question.
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