⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

August 28, 2024Anticancer ResearchOpen Access

Novel Diclofenac-NO Donor With High Affinity for Human Serum Albumin Induces Endoplasmic Reticulum Stress-mediated Cell Death in Human Pancreatic Cancer Cells

Koji Nishi RYO KANDA Kaho Takasaki Ayano Tamori Yoshifumi Arimura Shuhei Imoto HIROTAKA MURASE Kenji Tsukigawa Masaki Otagiri Keishi Yamasaki

View Full Paper

Ask AI

Bookmark

Share

Abstract

Nitric oxide (NO) has various physiological activities. In this study, diclofenac (DF) which has a high affinity for human serum albumin (HSA) was nitrosylated to a novel NO donor (NDF). The cytotoxic effects and the mechanism of NDF were investigated.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Nishi et al. (2024) studied this question.

synapsesocial.com/papers/68e5a94ab6db643587543093 https://doi.org/10.21873/anticanres.17204

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Ibuprofen‑derived nitric oxide donors with a high affinity to human serum albumin induce cell death in pancreatic cancer cells through a non‑caspase 3/7‑mediated pathway2024 · 2 citations
2Inflammation reduces osteoblast cytotoxicity induced by diclofenacIn Vitro Study · 2020 · 2 citations
3Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in <scp>H</scp>e<scp>L</scp>a cells through activation of <scp>AMPK</scp>2024 · 8 citations
4Diclofenac Sodium, a Nonselective Nonsteroidal Anti-Inflammatory Drug Aggravates Doxorubicin-Induced Cardiomyopathy in Ratspreclinical · 2010 · 17 citations
5Albumin as a Nitric Oxide-Traffic Protein: Characterization, Biochemistry and Possible Future Therapeutic Applicationspreclinical · 2009 · 21 citations

Nitrosonifedipine Ameliorates the Progression of Type 2 Diabetic Nephropathy by Exerting Antioxidative Effects2014
Synthesis, structural elucidation, and molecular docking of diclofenac-derived hydrazone metal complexes with anti-inflammatory and anticancer potential2025
Synthesis, structural elucidation, and molecular docking of diclofenac-derived hydrazone metal complexes with anti-inflammatory and anticancer potential2025
High Ubiquitin-like Protein 3 Expression Is Associated With Prolonged Recurrence-free Survival in Non-muscle-invasive Bladder CancerAnticancer Research · 2026
Distinct Clinical Pathways of Recurrent Cholangitis After Pancreaticoduodenectomy: Association With Hepaticojejunostomy Stricture and Early-onset CholangitisAnticancer Research · 2026

More from Anticancer Research

More from Sojo University