Figure 1 from Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures

ssSEs identify highly expressed genes unique to the ADRN and MES lineages. A, H3K27ac deposition on ADRN and MES SEs and ssSE in each neuroblastoma cell line. Peaks are higher for ssSEs than double-stranded SEs. B, H3K27ac deposition, KAS-seq pulldown, and RNA expression at MES ssSE, denoted in red, associated with a MES signature gene LUM in representative ADRN and MES isogenic cell lines and C, a ADRN signature gene PRIMA1 in the same representative cell lines. D, Heatmap representing 532 differentially expressed genes that were identified in five ADRN and three MES cell lines in proximity to ssSEs (P < 0.05).