Multifaceted Roles of 14-3-3 Proteins in Biological Processes: From Insect Physiology to Human Diseases

14-3-3 proteins are ubiquitous-sticky functional regulatory molecules entails for exerting an array of biological phenomenal processes across eukaryotes, including insects. They mainly execute their role by binding with specific targets of phospho-proteins, resulting multitude cross-talks among the signaling pathways crucial in transcendental cellular homeostasis. This particular factual review will be focused on underscores the underlying mechanism with multifaceted roles of 14-3-3 proteins in insect physiology with special emphasis on metamorphosis, early growth and developmental process in particular reproductive biology of the insect. Another facet of discussion is to unravel the arms race of strategic defense mechanism of insect against the challenged microbial pathogens would explain the unprecedented significant role in transcendental evolution of class insect. Unarguably intriguing quests are still appeared to be enigmatic in the insect crust to decipher the existence of orthologs functioning as like human patho-physiology situation gearing up of cancer progression, neurogenerative disorder and cardio-based insults. All together, these factual insights shed light on the scope of 14-3-3 proteins in myriad ways in normal and therapeutic strategy in control of the insect damage on the part of the plant and by developing a consortium of microbial flora against the insect pest is need of the hour for the researcher.