A chiral Zn–Sr heterobimetallic catalyst system generated in situ has been developed for the first highly Z/E-selective asymmetric conjugate addition of 3-acetoxy-2-oxindoles to alkynones. Both terminal alkynones and nonterminal alkynones could be applied to the heterobimetallic catalytic system. The corresponding 3-alkenyl-3-acyloxy-2-oxindoles were obtained in moderate to excellent yields (55–99%) with high E:Z ratios (8:1–30:1) and high enantioselectivities (86–99% ee).
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Zhou et al. (2024) studied this question.
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