Correlation of Body Mass Index, Age, Immuno-Biochemical Parameters of the Thyroid Panel With Intestinal Microbiota in Patients With Carbohydrate Metabolism Disorders and Thyroid Dysfunction

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The purpose of the study – to find out the correlations between the intestinal microbiotaand age, anthropometric indicators according to body mass index, immuno- biochemicalindicators of the thyroid panel in patients with carbohydrate metabolism disorders andthyroid dysfunction.Material and methods. The study included 89 patients with carbohydrate metabolismdisorders (type 2 diabetes mellitus, prediabetes, obesity) and thyroid dysfunction(autoimmune thyroiditis, hypothyroidism, Graves’ disease). Anthropometric indicators of height and weight; laboratory determination of immuno- biochemical parametersof carbohydrate metabolism and thyroid hormone were determined. To analyze thecomposition of the intestinal microbiota, fecal samples were taken and the quantitativeand qualitative composition was calculated using the principle of PCR sequencing.Statistical methods of comparison and correlation of variables were used.Results. In patients, several significant correlations were found between the gutmicrobiota and the parameters studied. A negative correlation was found between bodymass index and Bifidobacterium spp. and Escherichia coli and a positive correlationbetween body mass index and some opportunistic pathogens. Thus, with Shigella spp.and Staphylococcus aureus, there is a direct weak reliable relationship, while an inversereliable relationship with Helicobacter pylory. Interesting correlations were foundwith a tendency to confidence with Salmonella spp. and Bacteroides thetaiotaomicrondirect weak and a tendency to a plausible feedback between BMI and Faecalibacteriumprausnitzii and Candida spp. Bacteria of the phylum Firmicutes were inverselycorrelated with fT3 levels. Representatives of the phylum Bacteroidetes found a directcorrelation with fT3, TgAb. Clostridium perfringens was directly correlated with levelsof fT3, fT4, TRAb, TgAb, and Fusobacterium nucleatum was directly correlated withTPOAb. Interestingly, Candida spp. showed an inverse correlation with TPOAb, whileamong this genus of fungi, only Candida krusei was characterized by the appearanceof a correlation as a direct relationship with TRAb. Helicobacter pylory was directlycorrelated with TRAb and TgAb.Conclusions. 1. There are direct and inverse correlations between individualrepresentatives of the intestinal microbiota and body mass index. 2. Establishedcorrelations between individual representatives of the intestinal microbiome and thelevel of thyroid hormones and thyroid antibodies indicate the ability of the microbiometo influence the functional state of the thyroid gland through the mediation of the immunesystem.