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August 26, 2024Animal BioscienceOpen Access

ShRNA-interfered of Nrf2 reveals a critical role for Keap1-Nrf2 signaling pathway during effects of Zearalenone induced oxidative stress in IPEC-J2 cells

Qun Cheng Shu zhen Jiang Li bo Huang Wei Yang

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Abstract

This study aims to verify the protective effect of the Kelch-like ECH-associated protein1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways by studying the effect of plasmids containing Nrf2-small hairpin RNA (shRNA) interference down-regulation of Nrf2 on zearalenone (ZEA) -induced intestinal porcine epithelial cells (IPEC-J2) oxidative stress.

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Cite This Study

Cheng et al. (2024) studied this question.

synapsesocial.com/papers/68e5af05b6db643587548acb https://doi.org/10.5713/ab.24.0368

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Keap1-Kelch-targeting protein-protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environmentOriginal Research · 2025 · 6 citations
2Investigation of the Nrf2-Keap1 signaling pathway's response to oxidative stress in Meretrix meretrixOriginal Research · 2026
3Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE PathwayReview · 2006 · 3,620 citations
4Kelch-like ECH-associated Protein 1-nuclear Factor Erythroid 2-related Factor 2 Pathway Activation in Neuroprotection and Cognitive Enhancement2025
5Effect of atractylenolide III on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium2024 · 1 citations

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